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Biochemistry 41:22542263 Bae S, Oh K, Kim H, Kim Y, Kim HR, Hwang YI, Lee DS, Kang JS, Lee WJ (2013) The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion

In another study by Heath et al

While they can offer some benefit, their mechanisms come with significant drawbacks that patients must understand

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Patients who respond well to it describe feeling noticeably more alert, energized, and mentally clear, often within 24 to 48 hours of an infusion

Some specific types, like methylcobalamin, might even need to be refrigerated