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This is especially true when administered under proper medical supervision

Functional enrichment analysis further revealed that these genes were enriched in oxidative stressrelated pathways, including MAPK, Rap1, FoxO, and AMPK signaling pathways, which may contribute to the enhanced antioxidant capacity observed in PDHA1-overexpressing cells (Supplementary Fig

However, they are not FDA-approved for any human therapeutic use, and long-term safety data is limited

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Glutathione supplements are available from healthcare providers as well as online and in health stores

Although the importance of antioxidants, such as ascorbate and glutathione in human diseases, had long been recognized, it was only somewhat later that the interactions between ascorbate and glutathione were considered in animal systems (Meister, 1994)