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Tirzepatide is a dual agonist at GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors and produces enhanced glycemic control and greater weight loss compared to many GLP-1 RAs [34]

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2015-2021: SURPASS Clinical Program Eight Phase 3 trials enrolled over 13,000 participants with type 2 diabetes across diverse clinical scenarios [3] [4] : SURPASS-1: Monotherapy efficacy trial demonstrating HbA1c reductions of 1.87-2.07% across the 5-15 mg dose range SURPASS-2: Head-to-head superiority trial vs

And this necessitated the testing of the efficacy of exenatide in a Phase IIb double blind clinical trial