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Acetyl-CoA can then be oxidized to produce energy (ATP) in the citric acid cycle

This form of encephalopathy is similar to Wernicke encephalopathy that is the result of prolonged dietary deficiency of thiamine

Professional supervision: Such large doses are reserved for therapeutic or experimental purposes under medical guidance, as they go far beyond typical supplementation levels

AI and AI-assisted tools statement During the preparation of this manuscript, the AI tool ChatGPT (GPT-5, released 2025-08-07) was used to generate Figure 1 and the Graphical Abstract and to improve the readability and language of the manuscript

In the field of weight loss drug development, the recently disclosed clinical data of Amgens weight loss candidate drug Maridebart Cafraglutide (referred to as MariTide, formerly known as AMG 133) has drawn widespread attention in the industry and is considered a potential Game Changer. The reason why MariTide is seen as a game-changer in the weight loss drug market dominated by Wegovy and Zepbound is an important factor: MariTides molecular modality is a unique antibody-peptide conjugate (also known as Peptibody)

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