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The cellular phase of Alzheimer's disease

cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients

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The pathway is well-characterized

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The results indicated that dietary supplementation with 0.2 and 0.5% grape seed PCs significantly inhibited the formation of lipid peroxides induced by UVB exposure and reduced ROS levels in a dose-dependent manner in these murine models