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Clinical studies demonstrate minimal impact on cortisol levels (unlike GHRP-6 and GHRP-2), negligible prolactin elevation, and no significant effects on FSH, LH, TSH, or ACTH at therapeutic dosages

Cell Metab 15(6):827837 (Erratum in: 16(5):686) Mrquez J, Alonso FJ, Mats JM, Segura JA, Martn-Rufin M, Campos-Sandoval JA (2017) Glutamine addiction in gliomas

The deficiency of Nrf2 in Nrf2 knockout (KO) mice attenuated the chondroprotective effect of metformin on OA development, further affirming the core position of Nrf2 signaling during metformin fights illness as an antioxidant