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FDAs 2023 Category 2 placement cited immunogenicity risk for certain routes of administration, peptide-related impurities, complexities in active pharmaceutical ingredient (API) characterization, and limited safety information for the proposed routes

Although it was first identified in gastric juice , today it is synthesized in laboratories for research purposes

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The resulting poor overlap with the functions of class I GRXs might be advantageous in evolutionary terms

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