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In immune-deficient Shiverer mice, human iPSC-derived OPCs integrated with the host neonatal brain tissue after transplantation, differentiated to MBP expressing oligodendrocytes, remyelinated the dysmyelinated Shiverer axons, and constructed the nodes of Ranvier (Wang et al., 2013)

K.BellecA.et al

Pull the needle out the way it went in

Medically, a skin tan is recognized when the skin exhibits dual tones, a distinction between exposed and unexposed areas

508,509 Clinical presentation of Rett syndrome often includes aberrant breathing patterns, which can be mimicked in mice by astrocyte-specific deletion of MECP2 , 510 whereas re-introduction of the gene rescued abnormal breathing

A., El Rafei, R., Charafeddine, L