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Recently we have shown that GLP-1 activates afferent renal nerves to increase efferent renal sympathetic nerve activity that negates the diuresis and natriuresis produced by GLP-1 in normal rats [24]

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It upregulates the expression of genes involved in lipid and glucose metabolism while increasing mitochondrial density in skeletal muscle

Mice were anaesthetised with isoflurane (Isoflurin 1000 mg/ml, Axience, France) and positioned in a stereotaxic frame (Phymep Model 940 Small Animals)

1,25(OH) 2 D 3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice

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