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Synthetic peptides are engineered to improve bioavailability, target selectivity, and half-life, often surpassing the pharmacokinetic limitations of natural peptides. Vlieghe et al., Drug Discovery Today Do Natural and Synthetic Peptides Have Different Clearance Times

The clinical presentation can be insidious, with symptoms developing so gradually that patients may not recognise the changes until deficiency becomes severe

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Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis

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