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37 In terms of antimicrobial activity, berberine demonstrated strong effects against dysbiotic bacteria in IBS models, reducing the abundance of Escherichia/Shigella and Proteobacteria while enriching beneficial taxa such as Lactobacillus and Ruminococcus

For example, in spontaneous colitis (in C57BL/6 IL-10-/- mice) the enzyme was able to reduce histological and clinical signs of inflammation (129)

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doi: 10.1038/s41575020-00360-x 13 SiesH

21 CFR Parts 210-211

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