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Michael Alan, an endocrinologist I frequently consult with, puts it: "If you can buy it without a prescription, it's not an actual GLP-1 drug

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However, diabetes medications and weight loss drugs can cause different side effects, have different costs, and may work differently for each person

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The most common side effects are digestive: - Nausea (usually improves over time) - Vomiting - Diarrhea or constipation - Stomach pain These are usually manageable with slow dose increases

Some anti-inflammatory effects appear independent of weight loss, which is why microdosing is being explored for RA patients who aren't significantly overweight but have signs of metabolic inflammation