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Current Medicinal Chemistry, 25(30), 35773586

553 Fluid and salt intake should be encouraged to increase plasma volume, with a high-sodium diet potentially raising standing blood pressure and alleviating symptoms

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Additionally, some users may experience mild digestive discomfort or changes in bowel habits as their bodies adjust to the supplement

Certain acute conditionssuch as severe dehydration, sepsis, acute heart failure, or iodinated contrast dye proceduresmay require temporary metformin discontinuation even if kidney function is normal