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doi: 10.1016/j.aquatox.2017.12.017 30 HouWYulinHWenlongYTianTPengFYuqiongDet al

Dihexa exhibits blood-brain barrier penetration approximately 1000-fold more efficient than comparable peptide compounds, a remarkable property that fundamentally distinguishes it from most nootropic peptides

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10.1007/s00281-004-0176-0 34 GuilliamsM.SvedbergF

Granted those with MTHFR mutations need to be more careful around the use of synthetic substances and products as well as eat more of food that will help them detox and methylate but the adjustment only really looks hard on paper