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Energy restriction requires coordinated metabolic reorganization involving hepatic glucose output, adipose tissue lipolysis, skeletal muscle protein turnover, and mitochondrial fuel selection

Journal reference: Xie Y, Choi T, Al-Aly Z (2026)

Given the difficulty of losing weight and the complications that arise from obesity, bariatric surgery has become increasingly popular

Perdomo CM, Cohen RV, Sumithran P, Clment K, Frhbeck G

Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD (2008) The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome

Semaglutide GLP-1 injections are typically recommended for individuals with a BMI of 30 or higher, indicating obesity, or those with a BMI of 27 or higher and associated weight-related health conditions