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However, such a treatment would require coupling to FAO (106) and metabolic homeostatic mechanisms such as FA signaling (3) to prove successful

10.1016/S1474-4422(25)00026-2 131 MoradiG.ZinadiniS.RajabiL.Ashraf DerakhshanA

Lead with the Phase 3 miss: The most decisive data point is negative the pivotal CeD-Lara trial did not meet its primary endpoint and was discontinued in 2022, so larazotide has no approved indication and no established consumer dosing [6]

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A recent study has also suggested that GDH functions solely in glutamate oxidation rather than glutamate synthesis [75]