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Some clinics reported sourcing medications from pharmacies with regulatory concerns, including a lack of sterile compounding licenses or recent disciplinary actions

While body weight and metabolic phenotypes remain the primary endpoints, the outcome spectrum is progressively extending toward lipotoxic load [e.g., hepatic fat and visceral adipose tissue (VAT)], inflammatory/cardiometabolic risk markers, and reproductive outcomes with higher clinical decision-making value, such as menstruation, ovulation, and pregnancy

He was inducted into the Canadian Medical Hall of Fame, and in 2015 he was appointed Officer of the Order of Canada

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Vioxx lawsuits were consolidated into multidistrict litigation in 2005