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To spare the legal explanation, it is technically acceptable for a doctor to prescribe non-FDA-approved drugs if certain precautions are met [4]: After review, if the [doctor] decides that there is sound medical evidence and it is in the patients best interest to use a non-FDA approved device, he or she should conduct and document a thorough and careful informed consent discussion

The symptoms were improved by 27-82 percent and the greatest response occurred in patients with the lowest anxiety ratings

doi: 10.1038/12703 150 BoyleMPBrewerJAFunatsuMWozniakDFTsienJZIzumiYet al

Taguchi, A., Wartschow, L