These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005
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This has been the outcome of ardent manufacturer supported media campaigns about the almost preposterous effects of this molecule as a wonder drug for not only disorders of hyperpigmentation such as melasma, but also for general skin whitening. This article is meant to update healthcare professionals about the current status of efficacy, safety, and evidence of different formulations of glutathione for skin tone lightening