Heart rate acceleration with GLP-1 receptor agonists in type 2 diabetes patients: an acute and 12-week randomised, double-blind, placebo-controlled trial
Brand names include Ozempic, Wegovy, Mounjaro, and Zepbound
Glucagon-like peptide-1 (GLP-1) medications have emerged as powerful tools for weight loss
For comparison, transdermal medications that work well (like nicotine patches) involve molecules smaller than 500 daltons
Additional receptor destinations involve retrograde transport towards the Golgi apparatus ( Evidence from primary mouse islets and clonal beta cells (INS-1 832/3) shows that Exenatide causes a greater amount of GLP-1R degradation compared to endogenous GLP-1, with this effect apparently due to differences in the susceptibility of the agonists for degradation by the endopeptidase endothelin converting enzyme 1 (ECE1) (Metzler et al., 2001) is associated with the control of GLP-1R function
This effect is real, measurable, and one of the most therapeutically meaningful aspects of these medications
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