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Dehydration commonly produces symptoms including fatigue, headache, dizziness, muscle weakness, and general malaise, which patients may interpret as flu-like

However, abnormally high amounts could cause kidney damage and higher incidence of diarrhea and headaches

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These types of administration rituals are well-known to be associated with placebo effects, since regular rituals associated with medication administration can have psychological impacts on patients

Co-immunoprecipitation mass spectrometry and CRISPR knockout (KO) in mammalian cells identified mitochondrial m-AAA protease AFG3L2 as responsible for degrading SLC25A39 through the matrix loop 1