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In summary, this study demonstrates that the superior efficacy of dual GLP-1R/GCGR agonism versus single GLP-1 agonism in reducing obesity in DIO mice involves WAT lipolysis and remodeling towards beiging and UCP-1-dependent BAT activation

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Hyperlipidemia and enhanced oxidative stress Oxidative stress was enhanced in the hyperlipidemic rats, which was indicated by reduced GSH pool size and GSH/GSSG ratio

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