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Throw away any unused medicine after the beyond use date

When beta-catenin accumulates in the nucleus of dermal papilla cells (the "command center" at the base of each follicle), it activates transcription factors (LEF-1, TCF-1, TCF-3, TCF-4) that upregulate genes like c-Myc and cyclin D1

however, it is a rare side effect

Upon release, Nrf2 translocates to the nucleus where it can bind to the antioxidant response element (ARE) located in the promoter region of genes coding for antioxidant enzymes and scavengers

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Proper injection technique, site rotation, and appropriate dilution minimize reactions