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Although further experiments using electrophysiological technics are needed, these data suggest that hyper-glutamatergic neurotransmission and signaling in the PFC are involved in ASD-like behavior in these mice, which are consisted with previous electrophysiological report [53]

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In the SURMOUNT-4 trial, withdrawing tirzepatide after initial weight loss led to weight regain, while continued treatment maintained and extended weight reduction

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PMID 34449705