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[10] [11] A direct causal link with retatrutide has not yet been formally established, but the risk cannot be excluded Right upper quadrant pain, fever, or jaundice (yellowing of the skin or eyes), which may suggest gallbladder disease (such as gallstones or cholecystitis) another recognised class-related risk Severe constipation with vomiting, abdominal distension, and inability to pass wind, which may indicate intestinal obstruction or ileus and requires urgent assessment Symptoms that feel disproportionate or different in character from typical digestive upset In an emergency, contact NHS 111 or attend your nearest accident and emergency department

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