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doi: 10.1172/JCI4115

doi:10.1007/s00018-007-7218-4 Abeti R, Duchen MR

Cells with adequate NAD+ respond more effectively to insulin, improving glucose uptake and reducing the likelihood of insulin resistance developing or worsening

The peptide functions as an NNMT (nicotinamide N-methyltransferase) inhibitor, preventing methylation of nicotinamide into 1-methylnicotinamide

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When combined with lifestyle interventions like reduced-calorie diets and exercise, these mechanisms may accelerate visible changes in energy and body composition