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BPC 157 was studied almost exclusively by the same Croatian team that created it, doing rat study after rat study, while MK-677 was the domain of the Merck Research Laboratories in New Jersey, whose scientists conducted multiple small trials in humans in the 1990s, trying to see if the drug had interesting effects on a variety of surrogate markers

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Preclinical studies showed no adverse effects across several organ systems including liver, spleen, lung, kidney, brain, thymus, prostate, and ovaries in studies up to 6 weeks

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The epidural space is an area of the body where the spinal nerves are located and often inflamed resulting in significant pain and sometimes weakness