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To investigate the functional role of the R6 region in the SIRT1 promoter, a series of luciferase reporter constructs was obtained from VectorBuilder (USA), including a promoterless basic vector, a construct containing the full-length human SIRT1 promoter, including the R6 site, and promoter fragments corresponding to regions upstream and downstream of the R6 site that lack the R6 region (vector IDs: VB260105-1480rwj, VB260105-1503wsw, VB260105-1505cps, and VB260105-1513uay)

Hoff G, Bernklev T, Johnsen L, Reitsma L, Sina D, Lauzike A, Gibbs C, Carlsen E, Lende TH, Narvestad JK, Kildahl R, Omdal R, Kvaly JT, Siland H

Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice

When you suffer from B12 deficiency, the myelin sheath around your nerves is stripped away

B12 injections are absorbed straight into your bloodstream, making them faster-acting and potentially more effective

As a dietary supplement, 1 tablet two times daily on an empty stomach, or as directed by a healthcare professional