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6.4 Summary of RCTs In the RIPENACTB trial, adjunct NAC treatment with 1,200 mg twice a day in hospitalized HIV/TB patients significantly reduced circulating lipid peroxidation (malondialdehyde (MDA) levels by approximately 40%50%) and increased antioxidant defenses, including glutathione (GSH, by approximately 30%40%), compared to baseline and the standard care group

365,366,367,368,369 This region-specific activation suggests that UPR-mediated responses may vary depending on the type and extent of proteostasis disruption in different NDDs