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Topical treatments often pair glutathione with other actives like vitamin C, niacinamide, or alpha arbutin for synergy, and can be a good adjunct to oral or IV therapy

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Proc Natl Acad Sci U S A 100(7):41564161 Wagner M, Halilbasic E, Marschall HU, Zollner G, Fickert P, Langner C et al (2005) CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice