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When the epidermis of the treated area is inflamed, melanocytes (the skin cells responsible for pigment) are stimulated to increase melanin production

It was shown that prolonged sun-exposure is an important risk factor for melasma development, and can have a crucial role in enhancing each of these melanogenesis paths (Passeron and Picardo, 2018

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Therefore, people on vegetarian or vegan diets need to make sure they are getting enough B12 from other sources

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