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While categories such as salty snacks and candy are among those most likely to see a disproportionate reduction in consumption due to GLP-1s, users are additionally trading down in pack sizes in unexpected areas, including granola and coffee, according to Big Chalk

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The side effect profile of retatrutide is primarily gastrointestinal, driven by all three receptor systems but most acutely by GLP-1 mediated gastric emptying delay