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Interestingly, when comparing similar GLP-1R/GcgR dual-agonist sequences that differ in containing either the weak partial agonism-inducing Aib2 substitution, or the strong partial agonism-inducing substitutions of Aib2 and His3, the weak partial agonist [Aib2] exhibits superior and prolonged reductions in glycemic excursions and food intake relative to [Aib2, His3]

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Individual results depend on a combination of treatment compliance, starting health status, and the lifestyle changes you are willing to embrace alongside the medication