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And FDA regulators agreed, saying later that the substances present significant safety risks, because most have not been extensively tested in humans

GLP-1 medications have changed the game for weight loss, but not everyone sees the same results

The effect of long-term prednisone treatment on growth hormone and insulin-like growth factor-1

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Numerous gut- and brain-derived peptides exert potent anorectic or orexigenic effects, often with effect sizes comparable to or exceeding those of GLP-1 in preclinical models

However, they differ in a key way: tirzepatide is a dual agonist (GLP-1 and GIP), while retatrutide is a triple agonist (GLP-1, GIP, and GCG)