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Clinical manifestations, which are insidious in onset, include memory loss and cognitive decline (Scheltens et al., 2016)
Mutations of R-domain phosphorylation sites lead to loss of cadmium tolerance in Ycf1 11 and to lower open probability (but not overall open duration) and sensitivity to ATP concentration in the Ycf1 homolog CFTR 14,15
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In addition, they reported that B7-H3 induces EMT processes through downregulation of E-cadherin and upregulation of MMP-2 and MMP-9 expression via a JAK2/STAT3/Slug-dependent signaling pathway (120)
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