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Cell Metab 2017

Taken together, NAD partitioning, amino aciddependent redoxanabolic coupling, cofactor-dependent enzymatic throughput, and bile acidmediated absorption define key biochemical modules that may shape metabolic adaptation during chronic GLP-1RAinduced flux constriction

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The finding of GNAQ mutations in both nevus of Ota and uveal melanoma suggests a genetic link between these two lesions, and may provide the molecular basis for nevus of Ota being a risk factor for melanoma

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