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De hecho, las guas KDIGO para el manejo de pacientes con diabetes y ERC posicionan a los arGLP-1 como segunda lnea de tratamiento y los indican para pacientes con DM2 y ERC que no han alcanzado los objetivos glucmicos individualizados a pesar del uso de metformina e iSGLT2, o en los que no pueden utilizar estos medicamentos porque liraglutida, semaglutida y dulaglutida (no se haban publicado los resultados con epfeglenatida) han demostrado beneficios cardiovasculares, especialmente entre pacientes con enfermedad cardiovascular establecida, asociado a beneficios renales favorables con una reduccin sustancial de la albuminuria y probable preservacin del FGe112, as como otras guias en pacientes con DM2 y riesgo cardiovascular alto/muy alto, como son los pacientes con ERD19,113

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