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Further, targeted metabolomics results revealed that GGCT knockdown markedly attenuated TCA cycle flux, decreasing key intermediates including pyruvate, succinate and fumarate (Fig

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Phase I and II trials subsequently confirmed the predictable pharmacokinetics, dose-proportional efficacy, and manageable tolerability profile of semaglutide, allowing clear selection of therapeutic doses (0.5 mg and 1 mg s.c