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The five DEGs with the greatest up- and down-regulation changes are marked in each type of cell
Epithalon is a synthetic tetrapeptide with the sequence alanine-glutamic acid-aspartic acid-glycine (Ala-Glu-Asp-Gly, abbreviated AEDG)
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approximately 2% of brain cells were senescent, with excitatory neurons as the main contributing cell type (39)
Bcl-2 overexpression increases survival in human retinal pigment epithelial cells exposed to H(2)O(2)
Together, these peptides act on core hallmarks of aging: inflammation, oxidative stress, mitochondrial decline, and extracellular matrix degradation
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