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These miRNAs mainly include the miR-34 family (including miR-34a, miR-34b, and miR-34c), miR-206, miR-1, and other tumor suppressor miRNAs

Early symptoms include nausea, vomiting, and abdominal pain, but severe cases progress to liver failure and death if not treated promptly

Dose adjustment, slower titration schedules, or additional supportive measures can often alleviate symptoms whilst allowing continuation of therapy

Some people experience genuine food aversion during the first few weeks, where the thought of eating feels unpleasant

FOXO4 is localized within the promyelocytic leukemia body in senescent cells and interacts with p53, inhibiting its nuclear exclusion 34

Generally, CFs make synapses with the primary dendritic branches of PCs and PFs form synapses with the secondary and tertiary dendritic branches of PCs [43, 45]