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6 Emerging clinical applications 6.1 Non-alcoholic steatohepatitis (NASH)/non-alcoholic fatty liver disease (NAFLD) Studies investigating GLP-1 receptor agonists for the prevention of NAFLD/NASH indicate potential effectiveness via several molecular mechanisms
Some researchers studying metabolic parameters specifically choose to maintain at 8mg rather than escalating further, allowing for longer protocol durations with the same vial supply
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But the fat-burning signal from endogenous GH release is indirect and relatively weak compared to the direct triple-receptor activation that Retatrutide provides
Notably, 65.3% of participants taking retatrutide 12 mg achieved a BMI 22 at Week 80
10.1056/NEJMoa1509225 77 PsichasA.SleethM
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