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When you inject semaglutide, it travels through your bloodstream and activates GLP-1 receptors located in the hypothalamusthe part of your brain that controls hunger signals

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Its receptors are assembled from the calcitonin receptor (CTR) core combined with one of three receptor-activity-modifying proteins (RAMP1, RAMP2, or RAMP3), producing the amylin-receptor subtypes designated AMY, AMY, and AMY