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Current evidence does not establish that GLP-1 medications directly cause bone loss, though the substantial weight reduction they produce may influence bone density through indirect mechanisms

Journal of the Royal Asiatic Society Hong Kong Branch

Change from baseline in 5x chair rise fell an average 0.66 sec (P = 0.077), 10x chair rise time dwindled 1.27 sec (P = 0.069), and gait speed improved nonsignificantly (+0.05, P = 0.078)

These effects were more dramatic with the balanced agonist and interestingly the beneficial metabolic effects occurred with no change in oral nutrient intake in peptide vs control groups

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In study participants, the baseline A1c was 8.3% for both groups, and the baseline weight was 206 lbs