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Existing GLP1R agonists come with boxed warnings of thyroid cancer and pancreatitis, based mainly on rodent studies, where the effects of GLP1R agonism have noted species differences (For example, weight loss in rodents is mainly due to increased energy expenditure, whereas in humans it occurs via less food intake [54] )

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The real challenge may not be efficacy anymore, but how regulators and payers respond when demand signals move faster than formal evidence frameworks

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DOI: 10.1016/j.cmet.2022.07.013

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