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When sleep becomes fragmented or shallow: Pain sensitivity increases Inflammatory signaling rises Tissue repair slows Recovery capacity declines Sleep disruption alone can sustain chronic pain physiology, even in the absence of ongoing structural injury

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66 In a randomized, controlled phase 3 study by Jastreboff et al, no difference in gallbladder stone rates was observed between 5, 10, and 15 mg tirzepatide treatment and placebo in obese individuals over 72 weeks