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The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study randomized approximately 5,000 patients with relatively recent onset of T2DM (4.2 years) on metformin therapy to sulfonylureas, DPP-4 inhibitors, GLP-1 RAs, or insulin (16)
2004) was three-armed, and two studies (Lenzi et al
Studies suggest that people who lose weight quickly, particularly with the aid of medications like GLP-1 receptor agonists, may have a higher likelihood of developing gallstones, which can cause severe abdominal pain and may require surgical intervention
Anthony MS et al
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