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began enrolling dose-dependent, and durable reduction in CAPN2 mRNA and calpain-2 (Complete) Cohort 2 (n=12) in Canada protein levels in disease-relevant cell models of axonal degeneration Phase 1 LUMINA trial will evaluate the safety and biological activity of March 2026 Fully enrolled Cohort 2 (n=12) AMX0114 in people living with ALS (Complete) Early data from LUMINA show AMX0114 was generally well-tolerated for participants enrolled in Cohort 1 (n=12), with no treatment-related SAEs Present Cohort 1 biomarker 1H 2026 data at a medical meeting The FDA granted Fast Track Designation to AMX0114 in May 2025 providing eligibility for Priority Review if relevant criteria continue to be met ALS=amyotrophic lateral sclerosis

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The combined action of paracrine and endocrine produced GLP-1 on the GLP-1R of cell activates its downstream signaling pathway

If you're severely deficient, you may be prescribed up to 6,000 IU per day followed by a maintenance dose