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Nat Neurosci 9:119126 Shashidharan P, Huntley GW, Murray JM, Buku A, Moran T, Walsh MJ, Morrison JH, Plaitakis A (1997) Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody

Vagotomy in animal studies is said to disrupt the transfer of -synuclein derived from the gut to the CNS, but human observational evidence is inconsistent, with some studies indicating no change in PD incidence and others suggesting a reduced risk following truncal vagotomy (Elfil et al., 2020)

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High levels of saturated free fatty acids can cause ER stress that activates the UPR pathway by various mechanisms, such as inhibition of the enzyme that mobilizes ER Ca 2+ (i.e., ER Ca 2+ ATPase), activation of IP3 receptors, and/or directly impairing ER homeostasis (241)

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