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Misfolded wild type SOD1 is observed in sALS cases and the existing treatments for SOD1-related fALS, such as the antisense oligonucleotide therapy Tofersen, may have a possibility to be applied to these sALS cases (Marlow et al., 2025)

Xu W, Wan J, Zhan J, Li X, He H, Shi Z, et al

10.1016/j.compbiomed.2023.106637 109 MaC.JiangY.XiangY.LiC.XieX.ZhangY.et al (2025)

This isn't just about mixing solutions

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The TGA target timeframe for approval of priority medicines is 150 working days, excluding the time required for the sponsor to answer TGA questions, although the legislative timeframe has not changed and is the same as the standard pathway, 255 working days