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Then came the larger trial

Early demand for oral GLP-1s is likely to come from people already familiar with weight loss treatments, before awareness spreads more widely into the general public

Louis, Springfield, Columbia, Chicago, and more

The FDA allows and even encourages compounding pharmacies to produce and sell copycats when a drug is in short supply, and the wildly popular GLP-1 drugs have enduring shortages first reported in March 2022 for semaglutide and in December 2022 for tirzepatide

The takehome is simple: stronger evidence is coming, and it will focus on realworld outcomes rather than just biomarkers

The proximal tubule is also a major site for the regulation of the acid-base balance of the glomerular filtrate